Uncapped Gloucester centre Billy Twelvetrees will start for England against Scotland at Twickenham.
Twelvetrees comes in for Manu Tuilagi, while Joe Marler replaces Alex Corbisiero in two changes from the side that started against New Zealand.
Dylan Hartley, Toby Flood and David Strettle come on to the replacements' bench for David Paice, Freddie Burns and Jonathan Joseph respectively.
"We are happy to stick with the team that did so well against New Zealand, especially in light of the fact that they have all been in good form for their clubs since then," said England head coach Stuart Lancaster.
"There were some very tight calls, with some experienced players coming back into contention, and I am sure the bench will have a significant impact on the game.
"We can't wait to get back to Twickenham and hopefully experience the same atmosphere as the autumn when the crowd was superb. It means a lot to the players to have such support in the ground and watching on television."
England: 15 Alex Goode, 14 Chris Ashton, 13 Brad Barritt, 12 Billy Twelvetrees, 11 Mike Brown, 10 Owen Farrell, 9 Ben Youngs, 8 Ben Morgan, 7 Chris Robshaw (c), 6 Tom Wood, 5 Geoff Parling, 4 Joe Launchbury, 3 Dan Cole, 2 Tom Youngs, 1 Joe Marler.
Replacements: 16 Dylan Hartley, 17 David Wilson, 18 Mako Vunipola, 19 Courtney Lawes 20 James Haskell, 21 Danny Care, 22 Toby Flood, 23 David Strettle.
Date: Saturday, 2 February
Kick-off: 16:00 GMT
Referee: Alain Rolland (Ireland)
Assistant referees: JÃ©rÃ´me Garces (France), Francisco Pastrana (Argentina)
Television match official: Nigel Whitehouse (Wales)