Harlequins have made three changes to their starting XV - that lost to Exeter last weekend - for Friday's LV= Cup clash with Sale Sharks at the Stoop.
Darryl Marfo and Tom Williams are named, with 18 year-old number eight James Chisholm making his senior starting debut for the club.
Williams starts at full-back with Charlie Walker moving to the right wing. Centres Tom Casson and Tim Molenaar switch as the half-back partnership remains unchanged.
In the forwards, Marfo makes his first start of the season, joining Mark Lambert and Dave Ward in the front row.The final change to the forward pack sees Chisholm joining Joe Trayfoot and captain Luke Wallace in the back row.
Meanwhile, James Gaskell returns at flanker for the first time for Sale since breaking a bone in his foot in a warm-up match against Wasps.
Will Addison starts for the first time this season after an ankle operation and new signing Viliami Fihaki is named amongst the replacements.
Harlequins: 15 Tom Williams, 14 Charlie Walker, 13 Tom Casson, 12 Tim Molenaar, 11 Sam Smith, 10 Ben Botica, 9 Karl Dickson,8 James Chisholm, 7 Luke Wallace (c), 6 Joe Trayfoot, 5 Charlie Matthews, 4 George Merrick, 3 Mark Lambert, 2 Dave Ward, 1 Darryl Marfo.
Replacements: 16 Harry Allen, 17 Nic Mayhew, 18 Will Collier, 19 Tom Guest, 20 Matt Hopper, 21 Sam Stuart, 22 Louis Grimoldby, 23 Paul Sackey.
Sale Sharks: 15 Mike Haley, 14 Tom Brady, 13 Will Addison, 12 Mark Jennings, 11 Rob Miller, 10 Nick Macleod, 9 Dwayne Peel, 8 Mark Easter, 7 David Seymour, 6 James Gaskell, 5 Michael Patterson, 4 Jonathan Mills, 3 Henry Thomas, 2 Tommy Taylor, 1 Eifion Lewis Roberts.
Replacements: 16 Marc Jones, 17 Ross Harrison, 18 Tony Buckley, 19 Andrei Ostrikov, 20 Viliami Fihaki, 21 Will Cliff, 22 Danny Cipriani, 23 Charlie Ingall
Date: Friday, November 15
Kick-off: 19:45 GMT
Venue: Twickenham Stoop
Referee: Ian Tempest (England)
Assistant referees: Martin Fox (England), Phil Watters (England)
Timekeeper: Robert Ockenden (England)