Leeds Carnegie coach Neil Back has made ten changes, four of which are positional, to his side for this Sunday's home clash with London Irish.
England internationals Steve Thompson and Hendre Fourie return to the starting line-up in place of Phil Nilsen and James Craig. Daniel Browne reverts to the second row instead of Craig to allow Fourie to come in at openside flanker.
The other change in the pack sees Gareth Hardy come in at loosehead prop instead of Mike MacDonald, who is amongst the replacements.
The half-backs are completely changed with Adrian Jarvis alongside Scott Mathie and Lachlan MacKay switches from fly-half to inside centre. Luther Burrell comes into the centres alongside MacKay with Henry Fa'afili moving to the wing.
Finally, Michael Stephenson moves to full back in place of Ceiron Thomas, who is amongst the replacements.
Meanwhile, London Irish has made one change from the side that beat Harlequins in the Aviva Premiership last week with Jonathan Joseph coming in on the wing in place of Adam Thompstone for this weekend's fixture.
"It was good to get back to winning ways last week but this Sunday's fixture presents a fresh challenge," said boss Toby Booth.
"The boys have trained well and we know what is at stake. We're at the business end of the season now and so we will be going all out to build momentum and come away from the game with a win."
Leeds Carnegie: 15 Michael Stephenson, 14 Henry Fa'afili, 13 Luther Burrell, 12 Lachlan MacKay, 11 Peter Wackett, 10 Adrian Jarvis, 9 Scott Mathie, 8 Alfie To'oala, 7 Hendre Fourie, 6 Kearnan Myall, 5 Marco Wentzel (capt), 4 Daniel Browne, 3 Phil Swainston, 2 Steve Thompson, 1 Gareth Hardy.
Replacements: 16 Scott Freer, 17 Mike MacDonald, 18 Gareth Denman, 19 Sean Hohneck, 20 Danny Paul, 21 Warren Fury, 22 Ceiron Thomas, 23 Scott Barrow.
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Seilala Mapusua, 12 Dan Bowden, 11 Jonathan Joseph, 10 Chris Malone, 9 Paul Hodgson, 8 George Stowers, 7 Steffon Armitage, 6 Jamie Gibson, 5 Bob Casey, 4 Nick Kennedy, 3 Faan Rautenbach, 2 James Buckland, 1 Clarke Dermody (capt).
Replacements: 16 Rob Herring, 17 Max Lahiff, 18 Paulica Ion, 19 Kieran Roche, 20 Richard Thorpe, 21 Adam Thompstone, 22 Ryan Lamb, 23 Darren Allinson.
Date: Sunday, March 6
Venue: Headingley Carnegie
Referee: Rob Debney
Assistant referees: Rhys Davies, Llyr Apgeraint-Roberts