Seilala Mapusua will lead out London Irish for their match against Leeds Carnegie on Saturday as he marks his 100th appearance for the club.
The Samoan centre, who has racked up a century of caps in just four years, will become the first Pacific Islander to play a 100 times for the club.
London Irish Head Coach Toby Booth makes just one change from the side that convincingly beat Newcastle 46-12 last weekend, with England Saxons prop Alex Corbisiero coming in for Faan Rautenbach who moves to the bench.
Academy back Jonathon Joseph's fine form means he retains his place in the starting XV while prolific winger Sailosi Tagicakibau is named on the bench alongside fellow countryman Elvis Seveali'i.
"We've had an excellent start to the season so far and are in good shape for this weekend," said Booth.
"Last week's win over Newcastle counts for nothing if we don't get a positive result on Saturday and we are very focused on making sure that we continue our good form."
Meanwhile, Leeds Carnegie will travel to London looking for a repeat of their victory at the Madejski Stadium at the end of last season.
The Leeds team shows six changes to that which lost at Leicester last weekend.
Four of the changes come in the forwards with Andy Titterrell starting this week in place of Steve Thompson, Sean Hohneck coming in for his first start for the club in place of Tom Denton, Kearnan Myall swapping places with Rhys Oakley and Danny Paul starting his first game this season at number eight.
The two changes in the backline will see Luther Burrell back at inside centre after recovering from injury and Semi Tadulala replacing Lee Blackett on the wing.
Form: It's top meets bottom. London Irish have suffered just one reversal so far this season: 13-20 at Bath in round two. The Exiles' record in their last six Premiership games at Madejski Stadium is a less than impressive won three, lost three. Leeds Carnegie have lost their last five Premiership matches since their victory over Worcester at Headingley Carnegie on 25 April. Leeds return to the site of their most recent away victory, 23-13 at Madejski Stadium on 18 April. The Leeds victory in April ended a five game losing run against London Irish, whilst the Yorkshiremen's record at Madejski Stadium is a creditable won 3, lost 4.
London Irish: 15 Delon Armitage, 14 Topsy Ojo, 13 Seilala Mapusua , 12 Daniel Bowden, 11 Jonathan Joseph, 10 Ryan Lamb, 9 Paul Hodgson, 8 George Stowers 7 Declan Danaher , 6 Kieran Roche, 5 Bob Casey, 4 Nick Kennedy, 3 Alex Corbisiero, 2 James Buckland,1 Clarke Dermody (c).
Replacements: 16 David Paice, 17 Max Lahiff, 18 Faan Rautenbach, 19 Matt Garvey, 20 Jonathon Fisher, 21 Sailosi Tagicakibau, 22 Elvis Seveali'i, 23 Darren Allinson.
Leeds: 15 Leigh Hinton, 14 Mike Stephenson, 13 James Tincknell, 12 Luther Burrell, 11 Semi Tadulala, 10 Ceiron Thomas, 9 Scott Mathie, 8 Danny Paul, 7 Hendre Fourie, 6 Kearnan Myall, 5 Marco Wentzel (c), 4 Sean Hohneck, 3 Juan Gomez, 2 Andy Titterrell, 1 Mike Macdonald.
Replacements: 16 Steve Thompson, 17 Gareth Hardy, 18 Miguel Alonso, 19 Tom Denton, 20 Rhys Oakley, 21 Warren Fury, 22 Christian Lewis-Pratt, 23 Henry Faafili.
Date: Saturday, October 2
Venue: Madejski Stadium
Kick-off: 15.00 BST (14.00 GMT)
Referee: Greg Garner