Toulouse have given French internationals Yoann Maestri, Gaël Fickou and Maxime Médard a week off ahead of Saturday's Top 14 clash with Toulon.
Toulouse are precariously placed in sixth position as they face a high-pressure game against the European champions, who currently lie second.
But with their Heineken Cup quarter-final against Munster looming large on the horizon, Toulouse manager Guy Novès has decided to give the trio, who were part of France's Six Nations squad, a break and they will not travel to Stade Felix Mayol on Saturday.
French international wing Yoann Huget will return however having missed the clash against Stade Français in Paris last weekend. The same goes for fly-half Lionel Beauxis.
Centre Yann David and loose forward Yannick Nyanga are also both likely to return from injury layoffs.
Florian Fritz will start in midfield for the first time since December added Novès but Luke McAlister has been sidelined with a back injury sustained at the Stade de France last week. It is hoped he will be fit to face Munster.