Grenoble will be aiming to climb into the leading trio in the Top 14 standings as they travel to Bordeaux-Bègles on Friday.
In just their second season in the top flight, les Grenoblois have been the surprise package and currently lie in fourth place, just one point behind defending champions Castres and three clear of European champs Toulon, whom they shocked in Round 16.
Fabrice Landreau's side are undefeated since mid-December but will nevertheless face a stiff battle against a UBB outfit that have lost just once at home this season.
Bordeaux, who lie in 10th place, just three points clear of the relegation zone, know they must win or risk slipping in the dog fight for survival.
Grenoble welcome back Australian hooker Anthony Hegarty, who features for the first time since being knocked out against Stade Français in mid-December.
Loose forward Jonathan Best, who has just signed a two-year contract extension, will captain the side because both Andrew Farley and Fabien Gengenbacher have been named amongst the replacements.
Bordeaux-Bègles: 15 Darly Domvo, 14 Metuisela Talebula, 13 Felix Le Bourhis, 12 Thibault Lacroix, 11 Blair Connor, 10 Pierre Bernard, 9 Heini Adams, 8 Matthew Clarkin, 7 Hugh Chalmers, 6 Louis Madaule, 5 Adam Jaulhac, 4 Jandre Marais, 3 Albert Toetu, 2 Wayne Avei, 1 Jean Batiste Poux.
Replacements: 16 Clement Maynadier, 17 Benat Auzqui, 18 Jefferson Poirot, 19 Alikisio Fakate, 20 Poutasi Luafutu, 21 Emmanuel Saubusse, 22 Charles Brousse, 23 Silviu Florea.
Grenoble: 15 Benjamin Thiery, 14 Ratu alipate Ratini, 13 Geoffroy Messina, 12 Nigel Hunt, 11 Julien Caminati, 10 Blair Stewart, 9 Valentin Courrent, 8 Florian Faure, 7 Henry Vanderglas, 6 Jonathan Best, 5 Hendrik Roodt, 4 Benjamin Hand, 3 Dayna Edwards, 2 Laurent Bouchet, 1 Kenan Mutapcic.
Replacements: 16 Anthony Hegarty, 17 Albertus Buckle, 18 Andrew Farley, 19 Peter Kimlin, 20 Fabien Alexandre, 21 Fabien Gengenbacher, 22 James Hart, 23 Richard Choirat.
Date: Friday, February 7
Venue: Stade André Moga, Bègles
Kick-off: 20.45 (19.45 GMT)
Referee: Cyril Lafon