Dragons host Mogliano while I Cavalieri Prato travel to London Irish in Friday's European Challenge Cup clashes.
Dragons v Rugby Mogliano
Director of Rugby Lyn Jones has put his faith in several different faces to take on Mogliano Rugby in their first Challenge Cup game of the season.
Friday will be the second time the regional side take on the Italians at home on and they will be looking to keep their home winning streak intact.
Last week's man of the match Hallam Amos steps out of the wing and into the full-back position as Tom Prydie returns. Will Harries takes the other wing spot, whilst Adam Hughes and Ross Wardle make up the centre pairing.
International Kris Burton pulls on the number 10 jersey and Jonathan Evans steps into the scrum-half position. The front-row stays the same as last week's encounter against Zebre, as the second-row takes on a different form with young gun Matthew Screech and the experienced Rob Sidoli who will run out as captain this week.
British and Irish Lion Toby Faletau stays at number eight and is joined by Ieuan Jones and Nic Cudd in the back-row.
Dragons: 15 Hallam Amos, 14 Will Harries, 13 Adam Hughes, 12 Ross Wardle, 11 Tom Prydie, 10 Kristopher Burton, 9 Jonathan Evans, 8 Toby Faletau, 7 Nic Cudd, 6 Ieuan Jones, 5 Robert Sidoli (c), 4 Matthew Screech, 3 Nahuel Chaparro, 2 Sam Parry, 1 Owen Evans.
Replacements: 16 Elliot Dee, 17 Phil Price, 18 Dan Way, 19 Netani Talei, 20 Adam Jones, 21 Wayne Evans, 22 Jason Tovey, 23 Lewis Robling.
Mogliano: 15 Nicolo Fadalti, 14 Alberto Zorzi, 13 Giovanni Benvenuti, 12 Tommaso Boni, 11 Filippo Guarducci, 10 Edoardo Padovani, 9 Enrico Endrizzi, 8 Thorleif Halvorsen, 7 Andrea Ceccato (c), 6 Meyer Swanepoel, 5 Jacopo Bocchi, 4 Federico Maso, 3 Alessio Ceglie, 2 Ornel Gega, 1 Agustin Costa Repetto.
Replacements: 16 Ivan Gianesini, 17 Simone Ferrari, 18 Massimiliano Ravalle, 19 Marco Lazzaroni, 20 Andrea Trotta, 21 Antonio Giabardo, 22 Matt Cornwell, 23 Enrico Ceccato.
Date:Friday, October 11
Venue: Rodney Parade, Newport
Kick-off: 19:15 BST (18.15 GMT)
Referee: David Wilkinson (Ireland)
London Irish v I Cavalieri Prato
London Irish club captain, Declan Danaher, returns to the Exiles starting line-up and leads the Premiership side on Friday.
John Yapp, Jimmy Stevens and Jamie Hagan make up the front-row with Nic Rouse and Bryn Evans forming the second-row partnership. Blair Cowan, Jebb Sinclair and Declan Danaher make up the back-row.
Myles Dorrian and Darren Allinson make their first competitive starts this season in the halves with Sailosi Tagicakibau and Fergus Mulchrone in the centre. Andrew Fenby, Tom Fowlie and Alex Lewington make up the back three.
Brian Smith, Exiles director of rugby said: "We have rotated the squad this week to allow our squad players a chance to show what they can do. I Cavalieri Prato will be very passionate tomorrow night and will come to the Madejski looking to cause an upset so we have prepared accordingly for that."
London Irish: 15 Alex Lewington, 14 Tom Fowlie, 13 Fergus Mulchrone, 12 Sailosi Tagicakibau, 11 Andrew Fenby, 10 Myles Dorrian, 9 Darren Allinson, 8 Blair Cowan, 7 Jebb Sinclair, 6 Declan Danaher (capt), 5 Bryn Evans, 4 Nick Rouse, 3 Jamie Hagan, 2 Jimmy Stevens, 1 John Yapp.
Replacements: 16 Richard Palframan, 17 Johnny Harris, 18 Leo Halavatau, 19 George Skivington, 20 Ofisa Treviranus, 21 Topsy Ojo, 22 Shane Geraghty, 23 Tomas O'Leary.
I Cavalieri Prato: 15 Toby Browne, 14 Matte Falsaperla, 13 Denis Majstorovic, 12 Gabriele Manganiello, 11 Abou Souare, 10 TBC, 9 Pino Patelli (capt), 8 Gabriele Cicchinelli, 7 Diego Delnevo, 6 Alfonso Damiani, 5 Filippo Gerosa, 4 Alessandro Boscolo, 3 Rudy Biancotti, 2 Andrea Lupetti, 1 Robi Tenga.
Replacements: 16 Lorenzo Giovanchelli, 17 Cherif Traore, 18 Nicolas De Gregori, 19 Alberto Saccardo, 20 Leonardo Della Ratta, 21 Alessandro Lunardi, 22 Ivan Crestini, 23 Ale Devodier.
Date: Friday, October 11
Venue: Madejski Stadium
Kick-off: 20.00 BST (19.00 GMT)
Referee: Vlad Iordescu (Romania)