Sale will begin their quest for a third Challenge Cup title with a tricky fixture at home to Biarritz.
The Sharks won the title in 2002 and 2005 but will have their work cut out for them if they are to muster any kind of charge for glory this season.
The Pool One fixture gets the tournament underway on October 10, the same day that Bayonne welcome Grenoble to Stade Jean Dauger and Olympus Rugby Madrid make the difficult journey to face Stade Francais.
The following day, the Dragons play Mogliano while London Irish welcome Cavalieri Prato to the Madjeski Stadium.
In Pool One action on Saturday, Worcester Warriors pay a visit to newcomers Oyonnax while in Pool Two, Bordeaux-Begles face Bath. There are two Pool Three fixtures on the opening Saturday, with Newcastle heading to Bucharest and Calvisano hosting Brive.