Bulls coach Frans Ludeke has named Sampie Mastriet on the wing and Dewald Potgieter at number eight for Saturday's clash with the Sharks in Pretoria.
Both players will make their first Super Rugby appearances this year. Mastriet comes into the team in place of Akona Ndungane after a highly productive stint with the Springbok Sevens team and Potgieter joined up with the team following a season with his Japanese club Yamaha Jubilo and will take the place of Jono Ross.
Ndungane is still on compassionate leave following the passing of his father last week, whilst Ludeke opted for the experience of Potgieter at the base of the scrum.
Ross moves the bench, with Jacques Engelbrecht missing out in the only other change to the matchday 23.
"We have always maintained that you need a squad to win this competition and I am pretty please about the depth we have in ours," Ludeke told the Bulls' official website.
"Sampie has shown tremendous form with the Springbok Sevens team and brings a lot of pace into the back-line and Dewald has test match experience on top of being part of our system for many years. It is very pleasing to have them in the squad."
Bulls captain Flip van der Merwe said the recent upsurge in form is something the team is keen to continue with.
"Our first two away outings were pretty disappointing and everyone stepped up after that," he explained.
"We are keen to continue with the positive way we performed against the Lions and Blues.
"The Sharks are not topping the log for nothing, but we have prepared well for this one. We will be ready."
Bulls: 15 Jurgen Visser, 14 Sampie Mastriet, 13 JJ Engelbrecht, 12 Jan Serfontein, 11 Bjorn Basson, 10 Jacques-Louis Potgieter, 9 Francois Hougaard, 8 Dewald Potgieter, 7 Jacques du Plessis, 6 Deon Stegmann, 5 Victor Matfield, 4 Flip van der Merwe (capt), 3 Werner Kruger, 2 Callie Visagie, 1 Dean Greyling.
Replacements: 16 Bongi Mbonambi, 17 Marcel van der Merwe, 18 Paul Willemse, 19 Jono Ross, 20 Piet van Zyl, 21 Handré Pollard, 22 Ulrich Beyers, 23 Morné Mellet.
Date: Saturday, March 22
Venue: Loftus Versfeld Stadium, Pretoria
Kick-off: 19.10 local (17.10 GMT)
Referee: Mike Fraser (New Zealand)
Assistant referees: Craig Joubert (South Africa), Jaco van Heerden (South Africa)
Television match official: Deon van Blommenstein (South Africa)