Brumbies coach Jake White has made just one change to his team to face the Force, with Scott Sio at loosehead prop in the place of Dan Palmer.
Sio starts into the number one jersey with Ben Alexander moving across the scrum to tighthead prop and Palmer out of the matchday 22.
Ruaidhri Murphy makes his second appearance from the bench while Leon Power has also been included as a run-on reserve.
It's Power's first appearance for the 2013 season and he comes onto the bench for Jordan Smiler.
"As always with local derbies, we expect Saturday's match to be full of feeling and a tough contest right to the final siren," White said.
"The Force has a strong record against us here in Canberra, they almost got us here in Round One last year and in 2011 they had a big, come from behind win.
"They're a good team who have had some big wins over the last couple of weeks. It takes plenty of guts to overcome the Crusaders and the Reds and we will need to be at the top of our game to get a win on Saturday."
Brumbies: 15 Jesse Mogg, 14 Henry Speight, 13 Tevita Kuridrani, 12 Christian Lealiifano, 11 Joe Tomane, 10 Matt Toomua, 9 Nic White, 8 Ben Mowen (c), 7 George Smith, 6 Fotu Auelua, 5 Sam Carter, 4 Peter Kimlin, 3 Ben Alexander, 2 Stephen Moore, 1 Scott Sio.
Replacements: 16 Siliva Siliva, 17 Ruaidhri Murphy, 18 Leon Power, 19 Colby Faingaa, 20 Ian Prior, 21 Pat McCabe, 22 Robbie Coleman.
Date: Saturday, April 27
Venue: Canberra Stadium
Kick-off: 19:40 (09:40 GMT)
Referee: Angus Gardner (Australia)
Assistant referees: Andrew Lees (Australia), Matt O'Brien (Australia)
Television match official: Matt Goddard (Australia)