Bath prop David Wilson is the only change to England's starting XV for Saturday's important clash with Ireland at Twickenham.
Wilson replaces Dan Cole, who will require three months rest from rugby before further assessment on his neck, while the uncapped George Ford comes on to the replacements' bench for Brad Barritt.
"We are excited about being back at our home after two games on the road. The Twickenham crowd during the November internationals was superb and I'm sure it'll be the same again on Saturday," said England head coach Stuart Lancaster.
"We have been forced into one change and we wish Dan Cole all the best for his recovery. However, David Wilson is an experienced international with 31 caps and he showed in his three starts against Argentina last year what he can do.
"It's great to have George involved. He has settled in well and we are confident in his ability should he get his opportunity from the bench."
England: 15 Mike Brown, 14 Jack Nowell, 13 Luther Burrell, 12 Billy Twelvetrees, 11 Jonny May, 10 Owen Farrell, 9 Danny Care, 8 Billy Vunipola, 7 Chris Robshaw (c), 6 Tom Wood, 5 Courtney Lawes, 4 Joe Launchbury, 3 David Wilson, 2 Dylan Hartley, 1 Joe Marler.
Replacements: 16 Tom Youngs, 17 Mako Vunipola, 18 Henry Thomas, 19 Dave Attwood, 20 Ben Morgan, 21 Lee Dickson, 22 George Ford, 23 Alex Goode.
Date: Saturday, February 22
Kick-off: 16:00 GMT
Referee: Craig Joubert (South Africa)
Assistant Referees: Romain Poite (France), Leighton Hodges (Wales)
TMO: Jim Yuille (Scotland)