Ulster's Andrew Trimble will start on the wing as Brian O'Driscoll becomes Ireland's most capped player against Scotland.
O'Driscoll and Rob Kearney will both reach significant career milestones when they line out against Scotland at the Aviva Stadium on Sunday.
O'Driscoll will earn his 129th cap on Sunday and in doing so becomes Ireland's most capped player of all time while Kearney will claim his 50th cap for Ireland.
Paul O'Connell captain's the side and will be partnered in the second row by Devin Toner. The front-row is made up of Leinster duo Cian Healy and Mike Ross with Ulster's Rory Best at hooker.
The back-row sees Chris Henry come in at openside with Munster captain Peter O'Mahony on the blindside and Jamie Heaslip at number eight.
Conor Murray partners Johnny Sexton at half-back with Luke Marshall and Brian O'Driscoll partnered in the centre. The back three sees Rob Kearney at full-back and Dave Kearney and Trimble on the wings.
Ireland: 15 Rob Kearney, 14 Andrew Trimble, 13 Brian O'Driscoll, 12 Luke Marshall, 11 Dave Kearney, 10 Johnny Sexton, 9 Conor Murray, 8 Jamie Heaslip, 7 Chris Henry, 6 Peter O'Mahony, 5 Paul O'Connell (c), 4 Devin Toner, 3 Mike Ross, 2 Rory Best, 1 Cian Healy
Replacements: 16 Sean Cronin, 17 Jack McGrath, 18 Martin Moore, 19 Dan Tuohy, 20 Tommy O'Donnell, 21 Issac Boss, 22 Paddy Jackson, 23 Fergus McFadden
Date: Sunday, February 2
Kickoff: 15:00 GMT
Venue: Aviva Stadium
Referee: Craig Joubert (South Africa)
Assistant Referees: Jaco Peyper (South Africa), Mike Fraser (New Zealand)
TMO: Carlo Damasco (Italy)