Ulster quartet Paddy Jackson, Darren Cave, Craig Gilroy and Luke Marshall will all start in the Ireland XV that will take on Fiji in Limerick on Saturday.
Only Mike Ross, Conor Murray and Ireland captain Jamie Heaslip have been retained from the team that started against South Africa last weekend.
Former Ireland U20 fly-half Jackson will partner Murray in the half-backs with his provincial colleagues Marshall and Cave in the centres.
The back-three comprises the uncapped Gilroy on the left wing with Fergus McFadden on the right and Denis Hurley at full-back.
Up front David Kilcoyne, who won his first cap last weekend, completes the front-row with Sean Cronin while Dan Tuohy and Donncha O'Callaghan make up the second-row.
Heaslip anchors the scrum with Iain Henderson and John Muldoon named at six and seven.
Ireland: 15 Denis Hurley, 14 Fergus McFadden, 13 Darren Cave, 12 Luke Marshall, 11 Craig Gilroy, 10 Paddy Jackson, 9 Conor Murray, 8 Jamie Heaslip (capt), 7 John Muldoon, 6 Iain Henderson, 5 Dan Tuohy, 4 Donncha O'Callaghan, 3 Mike Ross, 2 Sean Cronin, 1 David Kilcoyne.
Replacements: 16 Richardt Strauss, 17 Cian Healy, 18 Michael Bent, 19 Donnacha Ryan, 20 Chris Henry, 21 Paul Marshall, 22 Jonathan Sexton, 23 Simon Zebo.
Date: Saturday, November 17
Kick-off: 17:30 GMT
Venue: Thomond Park, Limerick
Referee: Leighton Hodges (Wales)
Assistant referees: Neil Hennessy (Wales), Sean Brickell (Wales)
Television match official: Gareth Simmonds (Wales)