South African-born Leinster hooker Richardt Strauss is one of four uncapped players named in Ireland's 31-man squad for the November Tests.
Ireland will face South Africa, Fiji and Argentina in their three-Test series.
Ulster centre Luke Marshall and forward Iain Henderson, who were involved in the Ireland training camp in September, are included in the squad as are Munster prop David Kilcoyne and hooker Strauss, who is now eligible to play for Ireland based on his residency In Ireland for the past three years.
Leinster full-back Rob Kearney will miss the November internationals as he requires surgery on a troublesome back injury and could be sidelined for up to 10 weeks.
There are also changes to the Irish staff with Head Coach Declan Kidney being joined by current Munster assistant coach and former international Anthony Foley.
Foley will be now be leading the defence plans and systems allowing assistant coach Les Kiss to concentrate on attack and the backline.
Foley will continue working with Munster outside of the international window. It was also confirmed that Leinster scrum coach Greg Feek will continue providing his expertise to the Ireland team during competition time.
"We have three incredibly competitive games ahead of us in November and while there have been quite a few injuries and niggles in the early part of the season, it has opened up opportunities for other players to step into the squad," said Kidney.
"There are world ranking points on offer, so the underlying challenge for us is to work towards retaining and improving our ranking position ahead of the Rugby World Cup pool draw. While that is the end goal, our focus will be getting our preparations right to match the intensity of international games.
"I'm pleased that Anthony has taken up the offer of working with the squad to assist during this vital period in November. His previous experience of working with the team during the last RBS 6 Nations championship was important, but his own abilities and experience were central to bringing him onboard. I would like to thank Rob Penney and Joe Schmidt for being so positive and giving Anthony Foley and Greg (Feek) the scope to be part of the plans that we have."
Rory Best (Ulster), Tommy Bowe (Ulster), Darren Cave (Ulster), Tom Court (Ulster), Gordon D'Arcy (Leinster), Keith Earls (Munster), Stephen Ferris (Ulster), Cian Healy (Leinster), Jamie Heaslip (Leinster), Iain Henderson (Ulster), Chris Henry (Ulster), David Kilcoyne (Munster), Luke Marshall (Ulster), John Muldoon (Connacht), Conor Murray (Munster), Mike McCarthy (Connacht), Fergus McFadden (Leinster), Kevin McLaughlin (Leinster), Donncha O'Callaghan (Munster), Paul O'Connell (Munster), Brian O'Driscoll (Leinster - Captain), Ronan O'Gara (Munster), Peter O'Mahony (Munster), Eoin Reddan (Leinster), Mike Ross (Leinster), Donnacha Ryan (Munster), Jonathan Sexton (Leinster), Richardt Strauss (Leinster), Andrew Trimble (Ulster), Dan Tuohy (Ulster), Simon Zebo (Munster).