Dan Cole will miss the rest of the Six Nations and have a period of rest from rugby to relieve a bulging disc in his neck which is trapping a nerve.
The Leicester Tigers and England tight-head prop was diagnosed after experiencing weakness during a gym session at St George's Park last week and will miss the rest of the Six Nations.
Cole will have further specialist assessment on Tuesday evening.
"It's massively disappointing for Dan, Leicester and England but the important thing is that this has been diagnosed and that Dan gets the appropriate rest and treatment," said England head coach Stuart Lancaster.
"Our medics are working closely with Leicester's to come up with a programme that will ensure Dan returns in the best possible shape.
"In the meantime, it's great to have David Wilson back, as well as Henry Thomas who has trained well and came off the bench against Scotland and this will be an opportunity to develop experience in this area."
"It's very disappointing for us and for England, and obviously for Dan, but his long-term fitness is more important," said Leicester Tigers boss Richard Cockerill.
"He'll have time to get over this issue and come back when the medical teams are satisfied with his progress.
The following players reported to Pennyhill Park this evening to prepare for Saturday's Six Nations match against Ireland at Twickenham.
David Attwood, Dylan Hartley, Matt Kvesic, Tom Johnson, Joe Launchbury, Courtney Lawes, Joe Marler, Ben Morgan, Matt Mullan, Chris Robshaw, Ed Slater, Henry Thomas, Billy Vunipola, Mako Vunipola, David Wilson, Tom Wood, Tom Youngs
Chris Ashton, Brad Barritt, Mike Brown, Freddie Burns, Luther Burrell, Danny Care, Lee Dickson, Kyle Eastmond, Owen Farrell, George Ford, Alex Goode, Jonny May, Jack Nowell, Billy Twelvetrees, Anthony Watson, Ben Youngs