England prop Mako Vunipola has been ruled out of Saturday's Test against New Zealand at Twickenham with a knee injury, head coach Stuart Lancaster has announced.
The Saracens loosehead missed Saturday's victory over Argentina and will not be ready in time for England's last Test of the year.
Joe Marler, who started against the Pumas, was concussed at Twickenham but is expected to be ready in time to take a place on the bench against the world champions. Alex Corbisiero will start.
"Mako won't be playing. Joe's going through the mandatory recovery for concussion, but we're hoping he'll be OK," said Lancaster.
Scrum-half Ben Youngs has been given the green light to play after recovering from a hip injury and Lancaster is optimistic that wing Marland Yarde will also be fit.
Christian Wade is, however, "unlikely" to recover from a tight hamstring.