Leicester number eight Jordan Crane has been handed the captaincy duties for the England Saxons in Friday's clash with the Ireland Wolfhounds.
He's one of six internationals in the XV along with Matt Mullan, Paul Doran-Jones, Joe Simpson, Jordan Turner-Hall and Richard Wigglesworth.
Elliot Daly and Joel Tomkins are in the backline of a young Saxons outfit while Saracens pair George Kruis and Will Fraser will start in the back-row.
Four more replacements are also set to make their first appearances at this level with former England U20 trio Rob Buchanan, Shaun Knight and George Lowe joined by ex-Rugby League international Kyle Eastmond.
"This is a dynamic young side with an average age of less than 24 and the players have a chance to show that they can play a major part of the future of England Rugby over the coming years. The blend of forward power and pace in the back line makes it an exciting one to be involved with," said head coach Jon Callard.
"We're facing an experienced Irish side in this opening game and the challenge is to step up and deliver a high quality performance in front of a passionate crowd in Galway."
England Saxons: 15 Elliot Daly, 14 Christian Wade, 13 Joel Tomkins, 12 Jordan Turner-Hall, 11 Tom Biggs, 10 George Ford, 9 Richard Wigglesworth, 8 Jordan Crane (capt), 7 Will Fraser, 6 George Kruis, 5 George Robson, 4 Graham Kitchener, 3 Paul Doran-Jones, 2 Joe Gray, 1 Nick Wood.
Replacements: 16 Rob Buchanan, 17 Matt Mullan, 18 Shaun Knight, 19 Ed Slater, 20 Jamie Gibson, 21 Joe Simpson, 22 George Lowe, 23 Kyle Eastmond.
Date: Friday, January 25
Venue: The Sportsground
Referee: Ian Davies (Wales)
Assistant referees: Sean Brickell (Wales), Chris Williams (Wales)
Television match official: Nigel Whitehouse (Wales)
Assessor: Tim Aplin (Ireland)