The Stormers have named Peter Grant at full-back as Springbok captain Jean de Villiers returns to face the Lions at Newlands.
De Villiers resumes the team captaincy from Duane Vermeulen and will line up at inside centre, with Damian de Allende shifting back to the right-wing - in place of the injured Kobus van Wyk - for the Stormers' second all-South African encounter of the season.
In other changes amongst the backs this week, Nic Groom and Demetri Catrakilis return to form a new-look half-back combination for the Stormers, with Peter Grant shifting to full-back and Jaco Taute dropping down to the bench.
The Stormers pack remains unchanged from their previous clash - against the Waratahs in Cape Town two weeks ago - but there are a number of additions amongst the replacements.
Joining Taute on the bench this week are fit-again prop Pat Cilliers and lock Jurie van Vuuren - replacing the injured pair of Oli Kebble and Tazz Fuzani, respectively - whilst winger Devon Williams, the top try-scorer in the 2014 Vodacom Cup, comes into a Super Rugby matchday squad for the first time in his fledgling career.
"It's obviously great to welcome back Jean de Villiers this week, but so too Pat Cilliers and Jurie van Vuuren from injury," said head coach Allister Coetzee.
"Jurie is part of a youthful bench, four of whom were still playing Under-21 rugby last season and two who are still eligible for the DHL WP U21 team this year.
"We have never been afraid to give young players a chance at the DHL Stormers and it's always an exciting time when someone is on the verge of making his debut as is the case with Devon.
"We know that the Lions are a quality side, as they showed against us in Johannesburg earlier this season.
"We were poor at managing the Lions' contestable kicking game at Ellis Park and our line-out also didn't function well enough. It's a different venue, here at sea level, but we really have to ensure that our set-piece fires."
Stormers: 15 Peter Grant, 14 Damien de Allende, 13 Juan de Jongh, 12 Jean de Villiers (c), 11 Sailosi Tagicakibau, 10 Demitri Catrakilis, 9 Nic Groom, 8 Duane Vermeulen, 7 Siya Kolisi, 6 Nizaam Carr, 5 Michael Rhodes, 4 Ruan Botha, 3 Frans Malherbe, 2 Deon Fourie, 1 Steven Kitshoff
Replacements: 16 Stephan Coetzee, 17 Pat Cilliers, 18 Brok Harris, 19 Jurie van Vuuren, 20 Sikhumbuzo Notshe, 21 Louis Schreuder, 22 Devon Williams, 23 Jaco Taute
Date: Saturday, April 19
Venue: Newlands Stadium, Cape Town
Kickoff: 17:05 (local, 16:05 GMT)
Referee: Stuart Berry (South Africa)
Assistant Referees: Marius van der Westhuizen (South Africa) Quinton Immelman (South Africa)
TMO: Shaun Veldsman (South Africa)