Santiago Cordero will make his first start for Argentina when the Pumas face Wales in one of four changes to the side.
Cordero, 19, was a replacement against England last weekend having made his name in Sevens. He replaces Juan Imhoff on the left wing.
Manuel Carizza starts in the second row in place of Mariano Galarza, with Martin Landajo getting the nod over Tomas Cubelli at scrum-half.
The final change for the Pumas sees Joaquín Tuculet come in at full-back for Lucas González Amorosino, as Daniel Hourcade tinkers with his side for only his second match in charge.
Argentina produced an improved second-half performance against England last weekend, but were well-beaten 31-12 at Twickenham.
Hourcade will be hoping that Argentina can replicate last year's 26-12 success in Cardiff.
Argentina: 15 Joaquín Tuculet, 14 Horacio Agulla, 13 Marcelo Bosch, 12 Santiago Fernández, 11 Santiago Cordero, 10 Nicolás Sanchez, 9 Martin Landajo, 8 Juan Manuel Leguizamón (c), 7 Julio Farias Cabello, 6 Pablo Matera, 5 Patricio Albacete, 4 Manuel Carizza, 3 Maximiliano Bustos, 2 Eusebio Guiñazú, 1 Marcos Ayerza.
Replacements: 16 Santiago Iglesias Valdez, 17 Nahuel Lobo, 18 Matías Díaz, 19 Tomás Lavanini, 20 Leonardo Senatore, 21 Tomas Cubelli, 22 Gabriel Ascárate, 23 Lucas González Amorosino.
Date: Saturday, November 16
Venue: Millennium Stadium, Cardiff
Kick-off: 14:30 GMT
Referee: John Lacey (Ireland)
Assistant referees: Steve Walsh (Australia), Lourens van der Merwe (South Africa)
TMO: Simon McDowell (Ireland)