Lee Dickson has been selected at scrum-half by England to play Australia at Twickenham, as Joel Tomkins makes his Test debut.
Dickson, who started both Tests against Argentina in June, wins his 10th cap and partners Owen Farrell at half-back, while fellow British and Irish Lions Dan Cole, Ben Youngs and brother Tom also return to the match 23.
Tomkins will make his England debut at outside centre, whilst Saracens team-mate Billy Vunipola and London Irish wing Marland Yarde, who both won their first caps against the Pumas, will make their first starts at Twickenham.
"I'm delighted for Joel. He has had a great week's training and is ready for his chance. He has played in many high-profile games in his career so far and has a great temperament for the big occasion," said England head coach Stuart Lancaster.
"Billy Vunipola and Maland Yarde made a big impression in Argentina and it's going to be a special occasion for them to run out at Twickenham in front of 82,000 passionate supporters for the first time.
"We are looking forward to the challenge of playing Australia - they have made great strides under Ewen McKenzie and their new coaching team and they are formidable opponents.
"It's eight months since we played at our home (Six Nations v Italy) and we are looking forward to getting back there for the November Internationals and what is a very important series for us two years out from the World Cup."
England: 15 Mike Brown, 14 Chris Ashton, 13 Joel Tomkins, 12 Billy Twelvetrees, 11 Marland Yarde, 10 Owen Farrell, 9 Lee Dickson, 8 Billy Vunipola, 7 Chris Robshaw (c), 6 Tom Wood, 5 Courtney Lawes, 4 Joe Launchbury, 3 Dan Cole, 2 Tom Youngs, 1 Mako Vunipola.
Replacements: 16 Dylan Hartley, 17 Joe Marler, 18 David Wilson, 19 Dave Attwood, 20 Ben Morgan, 21 Ben Youngs, 22 Toby Flood, 23 Ben Foden.
Date: Saturday, November 2
Kick-off: 14:30 GMT
Referee: George Clancy (Ireland)
Assistant Referees: Romain Poite (France), Dudley Phillips (Ireland)
TMO: Marshall Kilgore (Ireland)