Bryan Redpath has made six changes to his Gloucester side ahead of facing Glasgow in their Heineken Cup clash.
Number eight Gareth Delve returns to skipper the side as the Cherry and Whites look to respond from their 33-11 defeat at Firhill, which ultimately prompted Redpath to make three changes in the backs and three in the pack.
In the back-line, England internationals Olly Morgan and Tom Voyce return at full back and on the wing respectively. It will be Voyce's 50th appearance in the competition. The final new face in the back line is Tim Molenaar who will partner James Simpson-Daniel in the centre.
In the front-row, new England cap Paul Doran-Jones starts at tighthead in place of All Black Greg Somerville. The second-row is unchanged but Fijian international Akapusi Qera is back at openside flanker with Alasdair Strokosch reverting to blindside to accommodate him. Gareth Delve takes up his usual berth at number eight and resumes the captaincy.
"I was disappointed with last Friday, of that there's no question. But, I'd never take anything away from Glasgow, they took their opportunities. So, credit to them," said Redpath.
"But we're back at home and that's key for us. We've got to get a reaction. We were hurting after that game last weekend and quite rightly so. We've lost too many and we're not happy about it.
"I haven't looked at the group table at all. It's not about that for me now. It's about the performance and winning the game. You can't be in the group if you don't win."
Meanwhile, Glasgow's bid to keep their quarter-final hopes alive have suffered a blow with star winger Thom Evans ruled out of Sunday's game at Gloucester.
Evans, who started Friday's 33-11 victory in the first of the Warriors' double-header with the English side, will not be risked due to a knee injury.
Head coach Sean Lineen has replaced both wingers for the game, with Dave McCall and Canada international DTH van der Merwe taking the places of Peter Murchie and Evans.
Captain Alastair Kellock has recovered from a chest infection and returns to the second row in the third change from last week's win at Firhill.
Lineen is expecting a backlash at Kingsholm this weekend saying: "Gloucester will be a real wounded animal because they are a very proud club.
"I thought we played very well at home. The boys are playing with real intent at the moment and it's a pleasure to watch them develop."
Gloucester: 15 Olly Morgan, 14 Charlie Sharples, 13 James Simpson-Daniel, 12 Tim Molenaar, 11 Tom Voyce, 10 Nicky Robinson, 9 Rory Lawson, 8 Gareth Delve (capt), 7 Akapusi Qera, 6 Alasdair Strokosch, 5 Alex Brown, 4 Dave Attwood, 3 Paul Doran-Jones, 2 Scott Lawson, 1 Nick Wood.
Replacements: 16 Darren Dawidiuk, 17 Alasdair Dickinson, 18 Greg Somerville, 19 Adam Eustace, 20 Luke Narraway, 21 Dave Lewis, 22 Eliota Fuimaono-Sapolu, 23 Carlos Spencer.
Glasgow: 15 Bernardo Stortoni, 14 Dave McCall, 13 Max Evans, 12 Graeme Morrison, 11 DTH van der Merwe, 10 Dan Parks, 9 Chris Cusiter, 8 Richie Vernon, 7 John Barclay, 6 Kelly Brown, 5 Richie Gray, 4 Alastair Kellock (c), 3 Moray Low, 2 Dougie Hall, 1 Jon Welsh.
Replacements: 16 Fergus Thomson, 17 Kevin Tkachuk, 18 Ed Kalman, 19 Dan Turner, 20 Colin Gregor, 21 Mark McMillan, 22 Johnnie Beattie, 23 Colin Shaw.
Date: Sunday, December 20
Kick-off: 12.45 GMT
Referee: Jérôme Garces (France)
Assistant referees: Patrick Pechambert (France), Jérôme Lamirand (France)
Television match official: Daniel Gillet (France)
Assessor: Brian Stirling (Ireland)