Sale and Northampton have named largely second-string sides for their Amlin Challenge Cup quarter-final clash at AJ Bell Stadium on Thursday.
Both teams are gunning for play-off spots in the Aviva Premiership, which sees names such as Sam Tuitupou, Johnny Leota, Danny Cipriani, Dave Seymour, George North, George Pisi, Tom Wood, Courtney Lawes and Dylan Hartley absent.
Sale have named Will Cliff and Nick Macleod as their half-back combination while Northampton select Lee Dickson and Will Hooley, with Kahn Fotuali'i backing the Saints up on the bench.
James Gaskell will captain the Sharks from blindside as Seymour and Dan Braid (injured) miss out so there are starts for Viliami Fahiki at number eight and Mark Easter on the openside.
Meanwhile, Northampton's back-three is Ben Foden, Ken Pisi and Fa'atoina Autagavaia, with Tom Stephenson and James Wilson the centres.
Phil Dowson will skipper the Saints in a back-row alongside Ben Nutley and Gerrit-Jan van Velze.
Sale Sharks: 15 Tom Arscott, 14 Tom Brady, 13 Andy Forsyth, 12 Mark Jennings, 11 Rob Miller, 10 Nick Macleod, 9 Will Cliff, 8 Viliami Fahiki, 7 Mark Easter, 6 James Gaskell (capt), 5 Kirill Kulemin, 4 Andrei Ostrikov, 3 Henry Thomas, 2 Tommy Taylor, 1 Ross Harrison.
Replacements: 16 Marc Jones, 17 Aston Croall, 18 Tony Buckley, 19 Jonathan Mills, 20 Michael Paterson, 21 Nathan Fowles, 22 Joe Ford, 23 Phil Mackenzie.
Northampton: 15 Ben Foden, 14 Ken Pisi, 13 James Wilson, 12 Tom Stephenson, 11 Fa'atoina Autagavaia, 10 Will Hooley, 9 Lee Dickson, 8 Gerrit-Jan van Velze, 7 Ben Nutley, 6 Phil Dowson (c), 5 James Craig, 4 Sam Dickinson, 3 Tom Mercey, 2 Ross McMillan, 1 Ethan Waller.
Replacements: 16 Matti Williams, 17 Danny Hobbs-Awoyemi, 18 Gareth Denman, 19 Christian Day, 20 Teimana Harrison, 21 Kahn Fotuali'i, 22 Dom Waldouck, 23 Jamie Elliott.
Date: Thursday, April 3
Kick-off: 20:00 BST
Venue: AJ Bell Stadium
Referee: Romain Poite (France)
Assistant referees: Peter Fitzgibbon (Ireland), Neil Paterson (Scotland)
TMO: Ian Ramage (Scotland)