England and Leicester fly-half Toby Flood will not be ready in time to face Treviso in Saturday's Heineken Cup clash at Stadio Comunale Monigo.
Flood has been sidelined by a toe injury suffered in England's 16-15 defeat to South Africa and Tigers director of rugby Richard Cockerill said at the club's pre-match press conference on Wednesday he would be out for a further week.
Flanker Steve Mafi is also out with a knee problem, but both are expected to return for next week's return to Premiership action.
George Ford is set to continue in the pivot role as Leicester look to do the double over the Italians and stay in touch with Pool 2 leaders Toulouse.
Fijian international flank Vereniki Goneva has also been ruled out with a knee injury. Goneva will probably be out for another four weeks.
Good news for Leicester fans is the expected return of Louis Deacon and Anthony Allen are both set to return to the match-day squad.