The Saxons have added Gloucester lock Elliot Stooke to the squad that is preparing to face the Ireland Wolfhounds at Kingsholm on Saturday.
Stooke, 20, replaces injured Leicester Tigers lock Graham Kitchener to join fellow Junior World Championship winners Henry Slade and Sam Hill in the 23-man group for the game being played on his home ground.
Three further injury replacements see Harlequins centre Matt Hopper, Sale Sharks full-back Rob Miller and Northampton Saints prop Tom Mercey take over from Bath Rugby's Jonathan Joseph, Mathew Tait (Leicester Tigers) and Harlequins' Will Collier.
Hopper, 28, featured in the 2012 victory over the Wolfhounds and Mercey, 26, has appeared in several of the Saxons' Churchill Cup campaigns but Miller, 24, will win his first cap at this level if he gets on the field at Kingsholm.
No replacements have been called up in place of Leicester Tigers wing Miles Benjamin and flanker Jamie Gibson, who will be reassessed at the end of the week with a view to being available for the match against Scotland A in Glasgow on January 31.