Gloucester have confirmed that full-back Olly Morgan has had to retire from professional rugby with immediate effect.
The former England international has been sidelined since tearing his lateral collateral and anterior cruciate ligaments in a Premiership fixture at Sixways against the Worcester Warriors in January 2012.
Since then, the 27-year-old has battled courageously in an attempt to get back to full fitness, undergoing a number of operations due to infection and exploring all possible recovery options, including a spell in America with renowned knee specialist Bill Knowles.
However, Morgan confirmed this week that he has reluctantly accepted that his knee would not be able to withstand the rigours of professional rugby.
"It's been such a difficult decision. Even though I've had a long time to consider this moment, it doesn't make it any easier," he said.
"The frustrating element is that we've actually made so much progress with my knee. I can't speak highly enough of the work that Bob Stewart and the medical team, and also Jamie Bain, have done with my rehabilitation.
"However, I have had to reluctantly accept that, the knee would not be able to cope with the stresses of matches week in and week out, as well as regular training sessions. It would just be too much."
Having a career end early is tough for any player, but the London born full-back insists that he will look back on his rugby career with fond memories.
"There have been so many great moments. I've loved every minute of my time as a Gloucester player, and I represented my country. Not many people can say that," he added.
"It's disappointing that I'm not able to bow out in the way that I'd like, but I've had so many highs and made so many great friends. You can't have any regrets when you look at it like that.
"I'd like to thank my team mates, the coaching staff, everyone who works at Kingsholm and the supporters of course. It's been a special experience.
"This particular chapter has come to an end. And it's disappointing that injury got the better of me. But that's a fact of life in modern rugby. It's all about the future now and I'm looking forward to exploring the various options available to me."