Cheetahs head coach Franco Smith has brought in Fred Zeilinga to start at fly-half for their Super Rugby clash with the Reds on Saturday.
Zeilinga takes the place of Niel Marais, who drops to the bench.
Smith has also made changes to his forward pack where Carl Wegner comes in for Francois Uys at lock and Henco Venter replaces the injured Hilton Lobberts.
Paul Schoeman subsequently moves from number eight to the side of the scrum for this weekend's match at Suncorp Stadium.
Cheetahs: 15 Clayton Blommetjies, 14 Sergeal Petersen, 13 Nico Lee, 12 Francois Venter, 11 Raymond Rhule, 10 Fred Zeilinga, 9 Shaun Venter, 8 Henco Venter, 7 Uzair Cassiem, 6 Paul Schoeman, 5 Lood de Jager, 4 Carl Wegner, 3 Maks van Dyk, 2 Torsten van Jaarsveld, 1 Charles Marais
Replacements: 16 Jacques du Toit, 17 Luan de Bruin, 18 Johan Coetzee, 19 Francois Uys, 20 Oupa Mohoje, 21 Tian Meyer, 22 Niel Marais, 23 Michael van der Spuy
Date: Saturday, April 30
Venue: Suncorp Stadium, Brisbane
Kick-off: 19:45 local (09:45 GMT)
Referee: Ben O'Keeffe
Assistant Referees: Will Houston, Nic Berry
TMO: George Ayoub