Saracens winger Chris Wyles will lead the USA in their World Cup opener against Samoa in Brighton on Sunday.
The versatile three-quarter has been named on the left wing by Mike Tolkin, opposite Biarritz flyer Takudzwa Ngwenya, with Blaine Scully completing a pacy back three.
Mike Petri and AJ MacGinty will combine in the half-backs, while up front Samu Manoa will be expecting to provide plenty of ball-carrying at number eight.
Elsewehere, young tighthead Titi Lamositele gets a start alongside Zach Fenoglio and Eric Fry in the front row, with Hayden Smith and Greg Peterson completing the tight five.
Samoa and the USA faced off in July during the Pacific Nations Cup, with Samoa winning 21-16 in San Jose.
USA: 15 Blaine Scully, 14 Takudzwa Ngwenya, 13 Seamus Kelly, 12 Thretton Palamo, 11 Chris Wyles (c), 10 AJ MacGinty, 9 Mike Petri, 8 Samu Manoa, 7 Andrew Durutalo, 6 Al McFarland, 5 Greg Peterson, 4 Hayden Smith, 3 Titi Lamositele, 2 Zach Fenoglio, 1 Eric Fry
Replacements: 16 Phil Thiel, 17 Oli Kilifi, 18 Chris Baumann, 19 Cam Dolan, 20 Danny Barrett, 21 Shalom Suniula, 22 Folau Niua, 23 Brett Thompson
Date: Sunday, September 20
Venue: Brighton Community Stadium, Brighton
Kick-off: 12:00 local
Referee: George Clancy (Ireland)
Assistant referees: Jaco Peyper (South Africa), Federico Anselmi (Argentina)
Television match official: Graham Hughes (England)