Wales will be without scrum-half Rhys Webb for the opening rounds of the Six Nations after it was confirmed he won't return until February.
Ospreys' medical department have said that Webb will only be back in action for them in late February, putting his international hopes in doubt.
Webb sustained a significant foot ligament injury in World Cup warm-up action and hasn't played since the game against Italy in September.
"His recovery is going well and we're now concentrating on getting him to the physical level he needs to be in order to perform as we want. He has begun running again, starting doing some skills work, and the focus is on getting him available for selection at the end of February, which would be five months post-op," said Chris Towers, Medical Performance Manager at the Ospreys.
Meanwhile, Ospreys forward Tyler Ardron is facing up to eight weeks on the sidelines, having undergone surgery in October on a knee problem sustained on World Cup duty for Canada.
"Tyler is suffering from a fused knee post surgery and on the advice of the specialist responsible for his care we need to give him time to let the swelling settle down, which means that he is looking at another six to eight weeks before he will be in a position to return to playing," said Towers.