Wales head coach Warren Gatland gave an update on the condition of Rhys Webb and Leigh Halfpenny after the side's win over Italy.
Losing one of the duo, let alone both, would be a disaster for Wales on the brink of the Rugby World Cup.
"Rhys is being scanned at the moment, so it’s not a break, we don’t know if it’s [ankle] ligament damage," Gatland told reporters.
"Leigh will be scanned tomorrow or Monday, it was his knee.
"It’s not great is it, you’ve got to feel for them if they are ruled out. You’ve got to put that behind you and work with the players you’ve got.
"Hopefully, Liam Williams will be taking full part in training next week. In the next 48 hours, when we get the scans back, we might have to assess our options."
Wales captain Sam Warburton tried to remain optimistic over the possible loss of two key players for his side in attempt to keep spirits high within the camp.
"Obviously, I’m going to be very optimistic and hope that if it is a ligament grade one or two then hopefully you can rehab that and be back in a few weeks," said Warburton.
"Sometimes it can feel worse than it is. When you see players down in a bit of pain it does effect the players.
"They both looked in fantastic shape and they’re two big players for us.
"Fingers crossed for the scan results on Monday. I’m going to be very optimistic until I hear otherwise."