Wales centre Jonathan Davies has been ruled out just two hours before kick-off for the game against Australia in Cardiff.
The British and Irish Lions back has been withdrawn after suffering a tight hamstring, according to WalesOnline.
Experienced replacement Scott Williams comes into the XV from outside of the matchday 23 to take over at outside centre for Wales, partnering Jamie Roberts in midfield.
Wales (revised): 15 Leigh Halfpenny, 14 Alex Cuthbert, 13 Scott Williams, 12 Jamie Roberts, 11 George North, 10 Dan Biggar, 9 Rhys Webb, 8 Ross Moriarty, 7 Justin Tipuric, 6 Dan Lydiate, 5 Luke Charteris, 4 Bradley Davies, 3 Samson Le, 2 Ken Owens, 1 Gethin Jenkins
Replacements: 16 Scott Baldwin, 17 Nicky Smith, 18 Tomas Francis, 19 Cory Hill, 20 James King, 21 Gareth Davies, 22 Sam Davies, 23 Hallam Amos
— Welsh Rugby Union ? (@WelshRugbyUnion) 5 November 2016