Italy have included two debutants in their side that will face Scotland on Saturday, with wing Michele Visentin and centre Enrico Bacchin named.
Missing from their Round Two game against England is Leonardo Sarto and Andrea Masi, who are replaced in the line-up by the aforementioned duo.
Simone Favaro comes in for Mauro Bergamasco on the flank while Joshua Furno replaces veteran Marco Bortolami in the second-row this weekend.
Dario Chistolini takes the place of the injured Martin Castrogiovanni, with Matias Aguero preferred ahead of Alberto de Marchi on the other side of the scrum.
Italy: 15 Luke McLean, 14 Michele Visentin, 13 Luca Morisi, 12 Enrico Bacchin, 11 Giovambattista Venditti, 10 Kelly Haimona, 9 Edoardo Gori, 8 Sergio Parisse, 7 Simone Favaro, 6 Francesco Minto, 5 Joshua Furno, 4 George Fabio Biagi, 3 Dario Chistolini, 2 Leonardo Ghiraldini, 1 Matias Aguero.
Replacements: 16 Andrea Manici, 17 Alberto De Marchi, 18 Lorenzo Cittadini, 19 Marco Fuser, 20 Samuela Vunisa, 21 Guglielmo Palazzini, 22 Tommaso Allan, 23 Giulio Bisegni.
Date: Saturday, February 28
Kick-off: 14:30 GMT
Referee: George Clancy (Ireland)
Assistant referees: Romain Poite (France), Leighton Hodges (Wales)
Television match official: Graham Hughes (England)
Assessor: Lyndon Bray (New Zealand)