Top 14 leaders Toulon are set to leave many of their stars at home for Sunday's top-of-the-table clash with Clermont.
Toulon travel to Parc des Sports Marcel Michelin for a rematch of the European Champions Cup Final, but Springbok wing Bryan Habana is likely to be the only member of the starting XV from Twickenham to retain his place.
The defending French champions are set to line up a never-seen-before backline combination although French international centre Maxime Mermoz will make his return from a wrist injury.
Scrum-half Eric Escande, young Australian fly-half Ulupano Seuteni and Fijian wing Josua Tuisova are expected to start with Jimmy Yobo joining Mermoz in midfield and David Smith set to wear 15.
Nevertheless, the RCT pack is likely to be well-stocked with international players as Italian prop Martin Castrogiovanni, South Africa hooker Craig Burden and Georgian loose forward Mamuka Gorgodze are set to be joined by French international locks Romain Taofifenua and Jocelino Suta plus former Clermont stalwart Gerhard Vosloo.
Toulon currently sit three points ahead of second-placed Clermont with two rounds of the regular season left to play.