Newly promoted Bayonne will host last year's runners-up Toulon on the opening day of the Top 14 season next month.
ProD2 champions Lyon meanwhile are also at home, as they take on Brive.
Racing 92 begin their title defence – having defeated Toulon in Barcelona last month – by travelling to Bordeaux-Bègles, while new La Rochelle signing Brock James could face an immediate reunion with his old side Clermont when les Jaunards travel to the Stade Marcel-Deflandre.
The remaining opening day fixtures see Castres host Pau, Stade Français take on Grenoble and play-off contenders from last season Toulouse and Montpellier face off to wrap up the first round of matches.
Top 14 Round One Fixtures – All games to be played on Saturday, August 20
Bayonne v Toulon
Bordeaux-Bègles v Racing 92
Castres v Pau
La Rochelle v Clermont
Lyon v Brive
Paris v Grenoble
Toulouse v Montpellier