Toulouse visit the Stade de France in French rugby's version of the superclassico while Clermont are seeking revenge against Perpignan.
It's the biggest weekend of Top 14 season so far: Toulouse visit the Stade de France in French rugby's version of the superclassico while Clermont host Perpignan for a rematch of last season's final.
If that isn't enough to whet your palate, fifth-placed Toulon are at home to struggling giants Biarritz while high-flying Racing-MÃ©tro face masters of the upset, Montpellier.
With just six games left in the regular season, clubs are gearing up for the final sprint to the line.
There's a crunch game for Bayonne, who must nab a bonus point win against Albi or face the prospect of joining their visitors in the ProD2 next season. Brive's chances of making the play-offs are getting ever slimmer and trip to leaders Castres probably won't help.
The return of the Six Nations internationals will boost a number of clubs, but with the current stop-start rhythm in the Top 14 smoothly reintegrating those player will be almost as much of a challenge as playing without them.
Of course not everyone will have all their Test players back since England are hanging onto their entire squad – much to the disgust of Stade FranÃ§ais who are paying James Haskell's salary in his absence are thus not happy with the idea of “funding England's preparations,” especially in light of Martin Johnson and co.'s visit to Paris in a fortnight
Friday, March 6
Clermont v Perpignan
Saturday, March 6
Castre v Brive
Bayonne v Albi
Bourgoin v Montauban
Toulon v Biarritz
Stade FranÃ§ais v Toulouse
Montpellier v Racing Metro
1 Castres 62
2 Perpignan 61
3 Clermont 61
4 Toulouse 56
5 Toulon 55
6 Racing-MÃ©tro 54
7 Stade FranÃ§ais 49
8 Brive 47
9 Biarritz 46
10 Montpellier 38
11 Montauban 37
12 Bourgoin 36
13 Bayonne 34
14 Albi 20
Friday, March 6
Clermont Auvergne v USA Perpignan
Parc des Sports Marcel Michelin, Clermont Ferrand
Level on points in second place in the standings, Clermont and Perpignan go head-to-head in the race of automatic semi-final qualification reserved for the top-two finishers of the regular season.
Unbeaten at home this season, Clermont have a full-strength squad and while the players refuse to talk of 'revenge' the crowd at Marcel Michelin will be baying for blood after defeat in last year's final and their heavy loss in Perpignan in September.
France wing AurÃ©lien Rougerie is back to skipper Clermont after recovering from the neck injury he sustained in the opening minutes of the Six Nations match against Scotland. No less than seven other internationals – Thomas Domingo , Julien Pierre, Alexandre Lapandry, Julien Bonnaire, Morgan Parra, Julien Malzieu and Davit Zirakashvili- return to the Clermont ranks while Italy centre Gonzalo Canale is given a rest.
For the visitors, who lost to Montauban two weeks ago, Maxime Mermoz is in the squad and as he makes his return from a long injury lay-off. Bleus Nicolas Mas and David Marty will also be on the train heading North.
Previous result: Perpignan won 19 -3
Prediction: Considering Clermont's record at home and Perpignan's form on the road the hosts must be favourites. Clermont to win by seven points
Kick-off: 20:45 (19.45 GMT)
Referee: JÃ©rÃ´me Garces
Saturday, March 6
Castres Olympique v CA Brive-CorrÃ¨ze
Stade Pierre Antoine, Castres
Still Undefeated at home this season, Castres will start the final sprint for play-off in pole position.
A draw against Racing Metro was enough to lift Castres back to the top on the standings but the Tarnais must travel to Toulon, Clermont and Toulouse in the final weeks so four more points this weekend are very much needed but Brive will provid a stiff challenge.
Beaten in Biarritz on their last outing, les Brivistes still harbour a glimmer of hope of making the play offs. A loss at Pierre Antoine would surely extinguish their chances.
Andy Goode is gone to the Shraks and Riki Flutey (who wants to go to Munster) is on duty with England. Better news however is that England hooker Steve Thompson and centre Jamie Noon are in the squad as well as Tricolors Alexis Palisson and Fabrice Estebanez.
Previous result: Brive won 11-9
Prediction:Castres by six points
Kick-off: 14:30 (13.30 GMT)
Referee: Laurent Cardona
Aviron Bayonnais v SCA Albi
Stade Jean Dauger, Bayonne
Bayonne captain RÃ©my Martin made his return after a 40-day suspension against Bourgoin last week, but it wasn't enough to stop the Basques from slipping back into the relegation zone.
Anything less than victory against relegation-certainties Albi could spell disaster.
Albi coach Eric Bechu has offered to resign (again) as a reaction to growing discontent amongst the players ranks, but club president Bernard Archilla has refused to accept the offer and has moved to dispel rumours of mutiny.
With tempers frayed on both sides, we can be sure of an explosive encounter, especially considering the fisticuffs of their previous meeting.
Previous result: Albi won 19-14
Prediction: We predict…a fight, a couple of cards and then a Bayonne victory by six points
Kick-off: 14:30 (13.30 GMT)
Referee: Eric Gauzins
Bourgoin-Jallieu v Montauban
Stade Pierre Rajon, Bourgoin
Bourgoin host their second vital relegation battle in as many weeks. Montauban's shock win over champions Perpignan last time out mean they are still one point clear of Bourgoin.
With Bayonne likely to win against Albi, the losers of the clash at Pierre Rajon are likely to find themselves in the drop zone.
Montauban will arrive full of confidence after the win over champions Perpignan two weeks ago, but will do well to remember Bourgoin how beat them on their own turf in September.
Previous result: Bourgoin won 12-15
Prediction: It'll be close and it'll probably be ugly. When in doubt, pick the home side. Bourgoin by a whisker
Kick-off:14:30 (13.30 GMT)
Referee: Pascal Gauzere
Toulon v Biarritz Olympique
Stade Felix Mayol, Toulon
Ninth and eight points off the pace in the play-offs race, Biarritz cannot afford to put a foot wrong until the end of the season.
Bad news for BO is, Toulon have yet to lose at home in a year – that'