Paul Williams will get Round Four underway when he blows the whistle in the meeting between the Hurricanes and the Force in Palmerston North.
Nick Bryant will officiate the clash between the Waratahs and the defending champions the Highlanders in Sydney, while Glen Jackson will be the man in the midle for the first South African derby of the weekend when the Bulls host the Sharks at Loftus.
Mike Fraser will travel to Tokyo to oversee the Sunwolves v Rebels game, with William Houston in charge in Christchurch when the Crusaders host the Kings.
Andrew Lees will signal the kick-off for the Reds and the Blues in Brisbane, and Stuart Barry will call the shots in the Lions v Cheetahs contest at Emirates Airlines Park.
Jaco Peyper will be the referee for the Stormers and the Brumbies in Cape Town, and Chris Pollock will end off the weekend's action when the takes to the field for the Jaguares v Chiefs battle in Buenos Aires.
Hurricanes v Force at Central Energy Trust Arena, Palmerston North
Referee: Paul Williams
Assistant Referees: Ben O'Keeffe, Kane McBride
TMO: Shane McDermott
Waratahs v Highlanders at Allianz Stadium, Sydney
Referee: Nick Briant
Assistant Referees: James Leckie, Graham Cooper
TMO: Ian Smith
Bulls v Sharks at Loftus Versfeld, Pretoria
Referee: Glen Jackson
Assistant Referees: Stuart Berry, Rasta Rasivhenge
TMO: Willie Vos
Sunwolves v Rebels at Prince Chichibu Memorial Stadium, Tokyo
Referee: Mike Fraser
Assistant Referees: Shuhei Kubo, Noriaki Hashimoto
TMO: Takashi Hareda
Crusaders v Kings at AMI Stadium, Christchurch
Referee: William Houston
Assistant Referees: Brendon Pickerill, Angus Mabey
TMO: Chris Wratt
Reds v Blues at Suncorp Stadium, Brisbane
Referee: Andrew Lees
Assistant Referees: Nic Berry, Jordan Way
TMO: Damien Mitchelmore
Lions v Cheetahs at Emirates Airlines Park, Johannesburg
Referee: Stuart Berry
Assistant Referees: Glen Jackson, Rasta Rasivhenge
TMO: Johan Greeff
Stormers v Brumbies at DHL Newlands, Cape Town
Referee: Jaco Peyper
Assistant Referees: Jaco van Heerden, Cwengile Jadezweni
TMO: Marius Jonker
Jaguares v Chiefs at Velez Sarsfield, Buenos Aires
Referee: Chris Pollock
Assistant Referees: Jamie Nutbrown, Federico Anselmi
TMO: Santiago Borsani