South Africa decided to release Scarra Ntubeni from the squad that remained in Durban ahead of their flight to Argentina.
Adriaan Strauss is set to start in Buenos Aires with Schalk Brits on the bench and Bismarck du Plessis also in the touring party.
“Scarra has been working very hard in the last month or so and is familiar with how we play," said Meyer.
"After consultation with all relevant role players, we decided that it would be in his best interest to some game time in the Currie Cup."
The Springboks were greeted by cold and wet weather when they arrived in Buenos Aires on Thursday.
Saturday’s Test at Vélez Sarsfield will be the Boks’ first encounter in the Argentine capital in almost a decade. The last time the South Africans played there was in November 2005.
South Africa have enjoyed good fortune in Buenos Aires before, but Springbok coach Heyneke Meyer is under no illusions about the enormity of the task that awaits his team.
“We were not good enough last week and the Pumas deserve full credit for their performance,” added Meyer.
“Saturday’s Test will be a massive challenge and we simply have to fire on all cylinders.”