The Sharks have made five changes to their starting lineup as they prepare to take on the Golden Lions in Durban on Saturday.
The Kwazulu-Natal side picked up their first win of the season last weekend against the EP Kings, but were not entirely convincing, while they take on a Lions team on a high after successive bonus point successes.
As a result Gary Gold has overhauled his backline, with a new-look centre partnership featuring Paul Jordaan and Andre Esterhuizen.
With Esterhuizen shifted from the wing, S'bura Sithole gets a start, while Michael Claassens comes in at scrum-half for his first Currie Cup start since returning from Europe.
In the pack Francois Kleinhans replaces Jean Deysel, with the final change seeing fit-again Dale Chadwick get the nod at loosehead in place of Juan Schoeman.
"Attacking rugby is the Lions’ DNA and we have to improve our defence," Gold told the Sharks website.
"The talk this week has been about an immense improvement for this weekend against the Lions and we know we are going to have to pitch up physically against the Lions."
Sharks: 15 Joe Pietersen, 14 Odwa Ndungane, 13 Paul Jordaan, 12 Andre Esterhuizen, 11 S'bura Sithole, 10 Lionel Cronje, 9 Michael Claassens, 8 Philip van der Walt, 7 Daniel du Preez, 6 Francois Kleinhans, 5 Marco Wentzel (c), 4 Etienne Oosthuizen, 3 Thomas du Toit, 2 Monde Hadebe, 1 Dale Chadwick
Replacements: 16 Franco Marais, 17 Gerhard Engelbrecht, 18 Dave McDuling, 19 Jean Luc du Preez, 20 Stefan Ungerer, 21 Wandile Mjekevu, 22 SP Marais
Date: Saturday, August 22
Venue: Kings Park, Durban
Kick-off: 17:05 local (15:05 GMT)
Referee: Quinton Immelman
Assistant Referees: Lourens van der Merwe, Jaco Kotze
TMO: Marius Jonker