Jonathan Sexton has been ruled out of Ireland's Rugby World Cup quarter-final against Argentina and is replaced by Ian Madigan.
Sexton has been replaced by Ian Madigan in Ireland's starting XV, with Paddy Jackson coming on to the bench.
"Post training yesterday Sexton tightened up and although scans earlier in the week were normal a further scan yesterday afternoon revealed a very minor adductor strain," read an update from the IRFU.
"It was therefore felt that it was better to withdraw him from the game rather than risk further injury. Ian Madigan will start at out-half and Paddy Jackson comes onto the bench."
Meanwhile, Isaac Boss has been brought in to the squad as further scrum-half cover in place of Jared Payne.
Ireland (revised): 15 Rob Kearney, 14 Tommy Bowe, 13 Keith Earls, 12 Robbie Henshaw, 11 Dave Kearney, 10 Ian Madigan, 9 Conor Murray, 8 Jamie Heaslip, 7 Chris Henry, 6 Jordi Murphy, 5 Iain Henderson, 4 Devin Toner, 3 Mike Ross, 2 Rory Best, 1 Cian Healy
Replacements: 16 Richardt Strauss, 17 Jack McGrath, 18 Nathan White, 19 Donnacha Ryan, 20 Rhys Ruddock, 21 Eoin Reddan, 22 Paddy Jackson, 23 Luke Fitzgerald
Date: Sunday, October 18
Venue: Millennium Stadium, Cardiff
Kick-off: 13:00 local (12:00 GMT)
Referee: Jérôme Garcès (France)
Assistant Referees: Romain Poite (France), Chris Pollock (New Zealand)
TMO: George Ayoub (Australia)