France head coach Guy Novès has named his line-up for their Six Nations opener against England at Twickenham on Saturday.
Baptiste Serin has got the nod over Maxime Machenaud at scrum-half and joins Clermont playmaker Camille Lopez in the half-backs.
With Wesley Fofana ruled out due to injury, the midfield for le Crunch will see Rémi Lamerat and Gaël Fickou link up while lethal wings Virimi Vakatawa, Noa Nakaitaci and full-back Scott Spedding complete the backline.
Up front Cyril Baille and Uini Atonio pack down either side of Guilhem Guirado, with Sébastien Vahaamahina and Yoann Maestri at lock.
Damien Chouly and Kévin Gourdon are named as flanks while Northampton Saints number eight Louis Picamoles also starts the fixture.
France: 15 Scott Spedding, 14 Noa Nakaitaci, 13 Gaël Fickou, 12 Rémi Lamerat, 11 Virimi Vakatawa, 10 Camille Lopez, 9 Baptiste Serin, 8 Louis Picamoles, 7 Kévin Gourdon, 6 Damien Chouly, 5 Yoann Maestri, 4 Sébastien Vahaamahina, 3 Uini Atonio, 2 Guilhem Guirado (c), 1 Cyril Baille
Replacements: 16 Clément Maynadier, 17 Xavier Chiocci, 18 Rabah Slimani, 19 Arthur Iturria, 20 Loann Goujon, 21 Maxime Machenaud, 22 Yoann Huget, 23 Jean-Marc Doussain
Date: Saturday, February 4
Kick-off: 16:50 GMT
Referee: Angus Gardner (Australia)
Assistant Referees: Glen Jackson (New Zealand), Marius van der Westhuizen (South Africa)
TMO: Peter Fitzgibbon (Ireland)