The Scarlets will be without a host of first team regulars against Leicester on Friday including the majority of their front row.
Props Samson Lee and Rhodri Jones will both be out, as will hookers Ken Owens and Emyr Phillips, with former Wales U20s hooker Kirby Myhill also injured.
That leaves coach Wayne Pivac in a difficult position ahead of the crucial game with the Tigers at Welford Road.
The New Zealander will also be missing Liam Williams, who is expected to return the following week against Toulon, while Gareth Davies is also missing after picking up a knock against Glasgow last weekend.
However it is in the front row where the Scarlets have been hit hardest, with Lee expected to be missing until the start of the Six Nations. Owens will be out longer than that, with a return not expected until mid-February.
“Samson Lee will be available for Welsh duties, but we won’t see him for the Toulon game and don’t expect to see him at the Scarlets until after the Six Nations,” announced Pivac.
“As for Liam Williams, it looks like a one-week injury. It’s a grade one AC joint, so Friday’s game is just too soon for him. He just needed another two or three days but it has settled down nicely and he should be available for Toulon.”