Karmichael Hunt could make his first appearance for the Reds since his suspension for possession of cocaine this Friday.
Hunt and flanker Liam Gill are both set to be involved against the Rebels, with Gill returning after his two-week ban for a dangerous tackle against the Brumbies.
"Having Karmichael and Gilly – (they) are two players that are really influential in the group," Reds captain James Slipper told AAP.
“We understand it’s going to be tough down in Melbourne but to have them in the team will be good.”
Second row Rob Simmons won't be ready in time for Friday but should be fit to face either the Bulls or the Cheetahs in the coming weeks.
Turning his attention to results, Slipper still believes that success for the Reds is around the corner.
“With the players we do have here, it’s a very good squad. Not only strong but it’s very deep. That’s what makes this squad very competitive," added Slipper.
“Unfortunately at the moment we haven’t had the best luck and we’ve started the season pretty slowly.
“In saying that, we took steps forward in the last game… it really did feel like the first run (of the season) for most of us with different players, different combinations.”