Reds head coach Nick Stiles has chosen to rest George Smith and Rob Simmons for Saturday’s clash wih the Jaguares at Vélez Sarsfield.
Already without suspended fly-half Quade Cooper and injured loosehead prop James Slipper, Stiles has opted to rotate his side this weekend.
Adam Korczyk is on the openside flank while young lock Izack Rodda takes over from Simmons, with Leroy Houston named on the blindside.
Jake McIntyre is at fly-half while hooker Stephen Moore returns to captain the side. Moore starts alongside Markus Vanzati and Sam Talakai.
Reds: 15 Karmichael Hunt, 14 Izaia Perese, 13 Samu Kerevi, 12 Duncan Paia’aua, 11 Eto Nabuli, 10 Jake McIntyre, 9 James Tuttle, 8 Scott Higginbotham, 7 Adam Korczyk, 6 Leroy Houston, 5 Kane Douglas, 4 Izack Rodda, 3 Sam Talakai, 2 Stephen Moore (c), 1 Markus Vanzati
Replacements: 16 Andrew Ready, 17 Kirwan Sanday, 18 Taniela Tupou, 19 Lukhan Tui, 20 Hendrik Tui, 21 Nick Frisby, 22 Lachie Maranta, 23 Chris Kuridrani
Date: Saturday, March 25
Venue: Vélez Sarsfield
Kick-off: 18:40 local (21:40 GMT)
Referee: Mike Fraser (New Zealand)
Assistant Referees: Jamie Nutbrown (New Zealand), Damian Schneider (Argentina)
TMO: Santiago Borsani (Argentina)