Al Kellock will make his 150th appearance for Glasgow Warriors when they take on Zebre in the Pro12 in Parma on Sunday.
Kellock, who is now into his ninth season at the club, will continue to captain the side from the second row.
The Warriors' last outing was in the narrow defeat to Bath Rugby in the European Rugby Champions Cup in January.
Peter Murchie comes in at full-back, while DTH van der Merwe continues on the left wing and Lee Jones returns from injury on the opposite side.
Richie Vernon returns to the Warriors back-line after playing at number eight against Bath and he'll form a new centre partnership with Fraser Lyle, who will be making his Warriors debut, after joining the club in November.
"We're looking forward to returning to action after a three-week break, but we'll face a tough challenge over in Parma on Sunday afternoon," Gregor Townsend told www.glasgowwarriors.org.
"This is an opportunity for a number of players to show what they are capable of and I'm delighted for Fraser (Lyle), who will be making his debut for the club."
Zebre will be led by back row Filippo Cristiano as they look to make it successive home wins following a victory over Brive in the Challenge Cup in January.
They welcome new signing Andrei Mahu, a Moldovan second row, while they will be able to call on an experienced backline including former All Black Brendon Leonard and veteran Italian three-quarter Mirco Bergamasco.
Form: Zebre's only victory in their last eight matches in all tournaments was 23-13 at home to Brive in the European Challenge Cup on 17th January. Zebre's most recent home win in the Guinness PRO12 came on 29th November when Edinburgh were the visitors. Glasgow Warriors have lost just one of their last five Guinness PRO12 encounters: 20-8 against Edinburgh at Murrayfield on 2nd January. The Scotsmen have lost their last four away games in all competitions since they won 15 -13 in Montpellier in the European Champions Cup on 25th October. In 24 previous fixtures against Italian opponents in all competitions, Glasgow have only been defeated on three occasions – all by Treviso and none since September 2011. The two sides have met four times before, the Warriors winning all four, two with a try bonus whilst Zebre have twice gained a losing bonus.
Zebre: 15 Hendrik Daniller, 14 Dion Berryman, 13 Tommaso Iannone, 12 Mirco Bergamasco, 11 Giulio Toniolatti, 10 Luciano Orquera, 9 Brendon Leonard, 8 Jacopo Sarto, 7 Filippo Cristiano (c), 6 Valerio Bernabò, 5 Augustin Cavalieri, 4 Andrei Mahu, 3 Luca Redolfini, 2 Oliviero Fabiani, 1 Andrea Lovotti
Replacements: 16 Luigi Ferraro, 17 Andrea De Marchi, 18 Luciano Leibson, 19 Federico Ruzza, 20 Ruben Riccioli, 21 Alberto Chillon, 22 Matteo Pratichetti, 23 Edoardo Padovani
Glasgow Warriors: 15 Peter Murchie, 14 Lee Jones, 13 Richie Vernon, 12 Fraser Lyle, 11 DTH van der Merwe, 10 Peter Horne, 9 Niko Matawalu, 8 Leone Nakarawa, 7 Tyrone Holmes, 6 James Eddie, 5 Al Kellock (c), 4 Tim Swinson, 3 Mike Cusack, 2 Pat MacArthur, 1 Alex Allan
Replacements: 16 Kevin Bryce, 17 Jerry Yanuyanutawa, 18 Rossouw de Klerk, 19 Josh Strauss, 20 Will Bordill, 21 Ali Price, 22 Connor Braid, 23 Rory Hughes
Date: Sunday, February 15
Venue: Stadio Sergio Lanfranchi, Parma
Kick-off: 14:00 local (13:00 GMT)
Referee: Leo Colgan
Assistant Referees: Matteo Liperini, Stefano Roscini
TMO: Stefano Penne