Luke McLean will start at fly-half for Treviso in their PRO12 clash this weekend against Leinster in Italy.
Jayden Hayward, the New Zealander, starts at full-back with Ludovico Nitoglia and Simone Ragusi on the wings. Andrea Pratichetti and Sam Christie start in midfield. Edoardo Gori and McLean are half-backs.
The front row is made up Matteo Zanusso, with Rupert Harden and Davide Giazzon.
Locks will be Marco Fuser and Filo Paulo. Finally, Francesco Minto, with captain Alessandro Zanni and Braam Steyn, will complete the XV chosen by Umberto Casellato.
Meanwhile, Leinster boss Leo Cullen has made nine changes in total to the starting XV with a host of Irish internationals returning and a debut in the second row for Maori All Blacks player, Hayden Triggs.
Isa Nacewa captains the side from full-back with Fergus McFadden again selected on the right wing. Dave Kearney who started in four games during the Rugby World Cup and scored a try against Canada comes onto the left wing.
Ben Te'o and Luke Fitzgerald start in the centre for the first time together although they have played there before in the PRO12 last season at home to the Dragons when Fitzgerald came on early in the game for the injured Noel Reid.
In the half backs, Eoin Reddan makes his first start in blue of the season, while outside him Johnny Sexton makes his first appearance since his return from Racing 92.
In the forwards, it is a completely new front row as Jack McGrath, Sean Cronin and Tadhg Furlong all start for the first time this season. Furlong did however feature off the bench last weekend against the Glasgow Warriors.
Former Blues second row Triggs makes his debut alongside Mike McCarthy who starts for the fifth time this season.
In the back row Rhys Ruddock starts again at blindside while Jordi Murphy comes in at openside for his 61st appearance in Leinster colours since his debut in September 2011. Wicklow man Jack Conan completes the pack from number eight.
Richardt Strauss, Cian Healy and Devin Toner are all in line to make their seasonal bows from the bench as Leinster go in search of a first away win of the season.
Form: Treviso slipped to a twelfth straight Guinness PRO12 defeat with their 12-9 reversal at Dragons on Friday. Treviso have not been victorious in the tournament since they beat Cardiff Blues at Stadio Monigo in February, whilst they have failed to defeat an Irish province since Connacht visited Treviso in October 2013. All five of Leinster's fixtures in the Guinness PRO12 this season have been won by the home side on the day, whilst Leinster's only away victory in their last eight trips in all competitions was over Edinburgh at BT Murrayfield in round 22 last season. The only time that Treviso have beaten Leinster in a dozen previous encounters in all tournaments was when the Irishmen visited Stadio Monigo in September 2010 and lost 13-29. The two sides played out a 24-all draw at the venue last November.
Treviso: 15 Jayden Hayward, 14 Ludovico Nitoglia, 13 Andrea Pratichetti, 12 Sam Christie, 11 Simone Ragusi, 10 Luke Mclean, 9 Edoardo Gori, 8 Abraham Steyn, 7 Alessandro Zanni (c), 6 Francesco Minto , 5 Teofilo Paulo, 4 Marco Fuser, 3 Rupert Harden 2 Davide Giazzon, 1 Matteo Zanusso
Replacements: 16 Luca Bigi, 17 Alberto De Marchi, 18 Simone Ferrari, 19 Jeff Montauriol, 20 Robert Barbieri, 21 Chris Smylie, 22 James Ambrosini, 23 Tommaso Iannone
Leinster: 15 Isa Nacewa (c), 14 Fergus McFadden, 13 Ben Te'o, 12 Luke Fitzgerald, 11 Dave Kearney, 10 Johnny Sexton, 9 Eoin Reddan, 8 Jack Conan, 7 Jordi Murphy, 6 Rhys Ruddock, 5 Mike McCarthy, 4 Hayden Triggs, 3 Tadhg Furlong, 2 Sean Cronin, 1 Jack McGrath
Replacements: 16 Richardt Strauss, 17 Cian Healy, 18 Marty Moore, 19 Devin Toner, 20 Josh van der Flier, 21 Luke McGrath, 22 Cathal Marsh, 23 Noel Reid
Date: Sunday, November 1
Venue: Stadio Monigo
Kick-off: 16:00 local (15:00 GMT)
Referee: Andy Brace (Ireland)
Assistant referees: Giuseppe Vivarini (Italy), Gregorio Piran (Italy)
Television match official: Stefano Roscini (Italy)
Assessor: Rosanno Faccioli (Italy)