Italy scrum-half Edoardo Gori will lead Treviso as they welcome Leicester Tigers to the Stadio Comunale di Monigo in the Champions Cup.
McLean is partnered at half-back by James Ambrosini, with Luke McLean also named at full-back.
Filo Paulo lines up in the second-row behind former Gloucester prop Rupert Harden for the PRO12 outfit.
Meanwhile, Telusa Veainu and Tommy Bell return to the Leicester Tigers backline.
Tonga international Veainu is named at full-back, with Bell returning at fly-half in the absence of Owen Williams.
Their return allows a reshuffle in the backline with Peter Betham restored to the wing and captain Mathew Tait at centre alongside Matt Smith.
Tom Croft returns to the forward back after missing the Round One win over Stade Francais last weekend with a back injury.
International quartet Matias Aguero, Dan Cole, Ben Youngs and Seremaia Bai are among the replacements, alongside club captain Ed Slater.
Tigers director of rugby Richard Cockerill said: "We made a really good start to the tournament with five points against Stade Francais last weekend but that will not count for much if we cannot follow up with another strong performance in Italy this weekend.
"We've got competition for places in the squad which means we can pick the freshest team available for this week and have a potential threat throughout the 23-man squad.
"Treviso are always a tough side to play against and on our last couple of visits we've needed late scores to get a win there, so we know we have to play well, we will have to be physical and we will have to be accurate."
Form: Leicester Tigers have won all eight matches against Treviso in the Champions Cup. Leicester Tigers have averaged 40 points scored per game against Treviso, twice recording 60 or more in their eight encounters. Treviso haven't beaten an English side since December 2004, losing all 21 games against opponents from England since then. Leicester Tigers have won all 20 matches against Italian opponents in the Champions Cup.
Treviso: 15 Luke McLean, 14 Ludovico Nitoglia, 13 Enrico Bacchin, 12 Sam Christie, 11 Tommaso Iannone, 10 James Ambrosini, 9 Edoardo Gori (c), 8 Abraham Steyn, 7 Francesco Minto, 6 Marco Barbini, 5 Jeff Montauriol, 4 Teofilo Paulo, 3 Rupert Harden, 2 Ornel Gega, 1 Matteo Zanusso.
Replacements: 16 Davide Giazzon, 17 Matteo Muccignat, 18 Filippo Filippetto, 19 Dean Budd, 20 Marco Lazzaroni, 21 Andrea de Marchi, 22 Chris Smylie, 23 Andrea Pratichetti.
Leicester: 15 Telusa Veainu, 14 Peter Betham, 13 Mathew Tait (c), 12 Matt Smith, 11 Vereniki Goneva, 10 Tommy Bell, 9 Sam Harrison, 8 Jordan Crane, 7 Brendon O'Connor, 6 Tom Croft, 5 Mike Fitzgerald, 4 Dom Barrow, 3 Fraser Balmain, 2 Tom Youngs, 1 Marcos Ayerza.
Replacements: 16 Greg Bateman, 17 Matias Aguero, 18 Dan Cole, 19 Ed Slater, 20 Lachlan McCaffrey, 21 Ben Youngs, 22 Seremaia Bai, 23 George Catchpole.
Date: Saturday, November 21
Venue: Stadio Comunale di Monigo
Kick-off: 14:00 local (13:00 GMT)
Referee: Mathieu Raynal (France)
Assistant Referees: Sébastien Minery (France), Vivien Praderie (France)
TMO: Hervé Dubes (France)