Oyonnax have made three changes to their starting XV that was set to start last week as they prepare to face Toulouse at Stade Ernest Wallon on Saturday.
Pierrick Gunther, Leon Power and Antoine Guillamon replace Valentin Ursache, Fabrice Metz and Marc Clerc in the line-up as flanker, lock and tighthead prop respectively for the all-French Champions Cup pool clash.
Fabien Cibray and Regis Lespinas remain as the half-back pairing which means Piri Weepu and Nicky Robinson must settle for places on the bench.
Oyonnax have named dangerous wings Fetu'u Vainikolo and Silvère Tian in their XV, with Toulouse needing to be wary of the threat that duo pose.
Meanwhile Toulouse have made several changes after their 32-7 loss to Saracens last week, with Toby Flood, Vincent Clerc and Sébastien Bézy dropped from the 23 altogether. In their place as starters are Clément Poitrenaud, Florian Fritz and Jean-Marc Doussain.
Thierry Dusautoir is also absent so in comes Imanol Harinordoquy while Talalelei Gray replaces Yacouba Camara on the other flank this week.
In the locks Romain Millo-Chluski gets the nod ahead of Joe Tekori while a brand new front-row sees Dorian Aldegheri, Christopher Tolofua and Vasil Kakovin start at tighthead, hooker and loosehead prop respectively.
Form: Oyonnax make their Champions Cup debut, becoming the 20th French team to participate in the competition. Toulouse have won nine and drawn one of their 11 matches against fellow French sides but this will be their first match in the Champions Cup against tournament debutants Oyonnax. Toulouse will be looking to avoid consecutive defeats on home soil for the first time in the Champions Cup; thus far they've played 65 matches at home without consecutive losses Toulouse have lost their last three in the competition, but have never suffered four consecutive defeats in the Champions Cup.
Toulouse: 15 Clément Poitrenaud, 14 Maxime Médard, 13 Gael Fickou, 12 Florian Fritz, 11 Timoci Matanavou, 10 Luke McAlister, 9 Jean-Marc Doussain, 8 Louis Picamoles, 7 Imanol Harinordoquy, 6 Talalelei Gray, 5 Romain Millo-Chluski, 4 Yoann Maestri (c), 3 Dorian Aldegheri, 2 Christopher Tolofua, 1 Vasil Kakovin.
Replacements: 16 Julien Marchand, 17 Nemiah Tialata, 18 Census Johnston, 19 Joe Tekori, 20 Gregory Lamboley, 21 David Mele, 22 Yann David, 23 Arthur Bonneval.
Oyonnax: 15 Florian Denos, 14 Silvère Tian, 13 Vincent Martin, 12 Eamonn Sheridan, 11 Fetu'u Vainikolo, 10 Regis Lespinas, 9 Fabien Cibray (c), 8 Viliami Ma'afu, 7 Olivier Missoup, 6 Pierrick Gunther, 5 Leon Power, 4 George Robson, 3 Antoine Guillamon, 2 Jody Jenneker, 1 Laurent Delboulbès.
Replacements: 16 Jeremie Maurouard, 17 Soane Tonga'uiha, 18 Marc Clerc, 19 Valentin Ursache, 20 Pedrie Wannenburg, 21 Piri Weepu, 22 Nicky Robinson, 23 Geoffrey Fabbri.
Date: Saturday, November 21
Venue: Stade Ernest Wallon
Kick-off: 16:15 local (15:15 GMT)
Referee: Matthew Carley (England)
Assistant Referees: Andrew Jackson (England), Robin Goodliffe (England)
TMO: Stuart Terheege (England)