Following back-to-back encounters with Leinster, there are six changes to the side for Harlequins against Newcastle.
Mark Lambert, Joe Gray and Kyle Sinckler start in the front row, while George Robson captains the side from an unchanged second row.
In the back-row Joe Trayfoot and James Chisholm, who makes his first Premiership start, are named alongside Jack Clifford.
Luke Wallace broke his hand last weekend and, after successfully undergoing surgery this week, is expected to return in six to eight weeks.
In the backs, Tim Swiel also makes his first Premiership start as Nick Evans continues his return from injury.
Meanwhile, Newcastle Falcons name a side with eight changes.
Heading back into league action after a European window which saw them put in two strong performances against Stade Fran