Harlequins have announced the squad to play Montpellier at The Stoop on Thursday in Round 1 of the Challenge Cup.
There are six changes to the squad that beat Sale Sharks in the Premiership last week.
Harry Sloan is named at inside centre as Matt Hopper moves to outside centre. Mike Brown, who recently announced that he is committing his long-term future to Harlequins, starts at full-back.
Adam Jones is recalled into the front row as Jack Clifford partners Luke Wallace and Nick Easter in the back row.
Among the replacements, Rob Buchanan will look to make his first appearance of the season, with Kieran Treadwell targeting a European debut.
Meanwhile, Fulgence Ouedraogo will captain Montpellier for their visit to London.
Head coach Jake White has completely changed his starting XV for the Challenge Cup opener, with the only survivor being Willem Liebenberg moving from six to seven.
Harlequins: 15 Mike Brown, 14 Marland Yarde, 13 Matt Hopper, 12 Harry Sloan, 11 Tim Visser, 10 Nick Evans, 9 Danny Care (c), 8 Nick Easter, 7 Luke Wallace, 6 Jack Clifford, 5 Sam Twomey, 4 Charlie Matthews, 3 Adam Jones, 2 Dave Ward, 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Kyle Sinckler, 19 Kieran Treadwell, 20 Chris Robshaw, 21 Karl Dickson, 22 Ben Botica, 23 Ollie Lindsay-Hague
Montpellier: 15 Jesse Mogg, 14 Benjamin Fall, 13 Timoci Nagusa, 12 Anthony Tuitavke, 11 Marvin O’Connor, 10 Francois Trinh-Duc, 9 Benoit Paillaugue, 8 Akapusi Qera, 7 Wiaan Liebenberg, 6 Fulgence Ouedraogo (c), 5 Paul Willemse, 4 Robins Tchale Watchou, 3 Nicolas Mas, 2 Craig Burden, 1 Mikheil Nariashvili.
Replacements: 16 Mickael Ivaldi, 17 Pat Cilliers, 18 CJ Van Der Linde, 19 Sitaleki Timani, 20 Kelian Galletier, 21 Ben Lucas, 22 Robert Ebersohn, 23 Julien Malzieu
Date: Thursday, November 12
Venue: The Stoop
Kick-off: 19:45 GMT
Referee: Ian Davies (Wales)
Assistant Referees: Simon Rees (Wales), Stuart Kibble (Wales)
TMO: Gareth Simmonds (Wales)