Friday's Premiership match will see Ugo Monye and George Robson appear in a Harlequins shirt for the last time at The Stoop when they face Bath.
Monye is the one change to the matchday squad which beat Sale Sharks, as he starts on the left wing; Charlie Walker is named among the replacements.
As Joe Marler continues his recovery from minor surgery, Chris Robshaw is named as captain.
Meanwhile, Bath welcome back tighthead prop David Wilson.
Wilson has recovered from the injury that ruled him out of England's 2015 Six Nations campaign to take his place in the starting team, packing down in the front-row alongside hooker Ross Batty and loosehead Paul James.
Dave Attwood and Dominic Day link up in the second-row, the pair having last started together there in Bath's famous win against Toulouse in January.
Francois Louw captains the side at openside flanker in a back-row also featuring blindside Sam Burgess and number eight Leroy Houston.
Peter Stringer and George Ford are retained at scrum-half and fly-half respectively, as is the midfield partnership of Kyle Eastmond and Jonathan Joseph. Horacio Agulla comes into the starting team at number 14, lining up with fellow wing Matt Banahan. Anthony Watson starts at full-back.
Form: Bath have not reached the semi-finals since 2010 but a win at Twickenham Stoop on Friday would secure a top-four finish with one round still to go. The West Country side are certainly one of the form sides having won their last four league matches while they hold the second best away record in the competition behind league leaders Northampton Saints. They have also defeated Harlequins twice this season, 25-6 in the league at the Rec in November and 23-21 in the LV= Cup in January. Quins are building up a head of steam having lost just once in their last four games – that defeat coming against Saracens at Wembley in March. The top four is out of reach – the first time Harlequins have missed out on the semi-finals since 2011 – although slim hopes of qualifying for the European Rugby Champions Cup remain.
Harlequins: 15 Ollie Lindsay-Hague, 14 Marland Yarde, 13 George Lowe, 12 Harry Sloan, 11 Ugo Monye, 10 Nick Evans, 9 Danny Care, 8 Jack Clifford, 7 Chris Robshaw (c), 6 Luke Wallace, 5 George Robson, 4 Nick Easter, 3 Matt Shields, 2 Dave Ward, 1 Mark Lambert
Replacements: 16 Rob Buchanan, 17 Seb Adeniran-Olule, 18 Darryl Marfo, 19 Charlie Matthews. 20 Netani Talei, 21 Karl Dickson, 22 Ben Botica, 23 Charlie Walker
Bath: 15 Anthony Watson, 14 Horacio Agulla, 13 Jonathan Joseph, 12 Kyle Eastmond, 11 Matt Banahan, 10 George Ford, 9 Peter Stringer, 8 Leroy Houston, 7 Francois Louw (c), 6 Sam Burgess, 5 Dominic Day, 4 Dave Attwood, 3 David Wilson, 2 Ross Batty, 1 Paul James
Replacements: 16 Rob Webber, 17 Nick Auterac, 18 Max Lahiff, 19 Matt Garvey, 20 Carl Fearns, 21 Chris Cook, 22 Ollie Devoto, 23 Tom Homer
Date: Friday, May 8
Venue: The Stoop, London
Kick-off: 19:45 local (18:45 GMT)
Referee: Greg Garner
Assistant Referees: Ashley Rowden, JP Doyle
TMO: Rowan Kitt