One year after Saracens blew Clermont away at Twickenham the teams meet for what could be effectively a knock-out match.
By the time the match at the Marcel Michelin kicks off, the sides will know exactly what they need to reach the last eight, and there is every chance the loser of this game is knocked out of the tournament.
That means that Saracens may need to become the first team to win in Clermont in European competition since Sale managed to do so in 2008.
Of course recent form will give Sarries confidence, they followed up their thumping 46-6 win in last year’s semi-final with a 30-23 win in round one over Clermont, a game in which they secured a maximum five points, although it was tight for much of the match.
They were also hugely impressive last weekend as they cruised past Munster, ending the Irish province’s hopes of reaching the quarter-finals in the process.
While that was a great performance, a win in the Massif Central would be another step up, with the home side chasing not only a spot in the last eight, but also a home quarter if they win.
They will have to do so without iconic centre Aur